Leng L, McAllister A, Zhang B, Radisic M, Gunther A (2012). Mosaic hydrogels: one-step formation of multiscale soft materials. Advanced Materials, 24(27), pp. 3650–3658
The one-step, continuous formation of mosaic hydrogel sheets is presented. A microfluidic device allows controllable incorporation of secondary biopolymers within a flowing biopolymer sheet followed by a cross-linking step that retains the microscale composition. Information is encoded; mosaic stiffness and diffusivity patterns are created; tessellations are populated with biomolecules, microparticles and viable primary cells; and 3D soft material assemblies are demonstrated.
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Mosaic hydrogels: one-step formation of multiscale soft materials 2016